Which statement best describes the relationship between cancer and oncogenes

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Oncogenes and tumor suppressor genes

which statement best describes the relationship between cancer and oncogenes

Mutation in tumor suppressor gene leads to cancer

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NCBI Bookshelf. Cooper GM. The Cell: A Molecular Approach. Sunderland MA : Sinauer Associates; Cancer results from alterations in critical regulatory genes that control cell proliferation, differentiation, and survival. Studies of tumor viruses revealed that specific genes called oncogenes are capable of inducing cell transformation, thereby providing the first insights into the molecular basis of cancer.

Differentiate between the actions of oncogenes and tumor suppressor genes in the development of breast cancer. Describe the results of studies with antibodies and small molecule drugs that target growth factor receptors. Evaluate the current and potential roles of molecular and protein profiles of breast tumors in prognosis and in predicting response to therapy. Carcinogenesis is a multistep process characterized by genetic alterations that influence key cellular pathways involved in growth and development. Oncogenes refer to those genes whose alterations cause gain-of-function effects, while tumor suppressor genes cause loss-of-function effects that contribute to the malignant phenotype.

This page has been archived and is no longer updated. Mutations in proto-oncogenes are typically dominant in nature, and the mutated version of a proto-oncogene is called an oncogene. Often, proto-oncogenes encode proteins that function to stimulate cell division , inhibit cell differentiation , and halt cell death. All of these processes are important for normal human development and for the maintenance of tissues and organs. Oncogenes, however, typically exhibit increased production of these proteins, thus leading to increased cell division, decreased cell differentiation, and inhibition of cell death; taken together, these phenotypes define cancer cells. Thus, oncogenes are currently a major molecular target for anti-cancer drug design.

An oncogene is a gene that has the potential to cause cancer. Most normal cells will undergo a programmed form of rapid cell death apoptosis when critical functions are altered and malfunctioning. Activated oncogenes can cause those cells designated for apoptosis to survive and proliferate instead.
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Two of the main types of genes that play a role in cancer are oncogenes and tumor suppressor genes. Proto-oncogenes are genes that normally help cells grow. When a proto-oncogene mutates changes or there are too many copies of it, it becomes a "bad" gene that can become permanently turned on or activated when it is not supposed to be. When this happens, the cell grows out of control, which can lead to cancer. This bad gene is called an oncogene. It may be helpful to think of a cell as a car.

NCBI Bookshelf. Molecular Cell Biology. New York: W. Freeman; As noted in the previous section, tumor cells differ from their normal counterparts in many respects: growth control, morphology, cell-to-cell interactions, membrane properties, cytoskeletal structure, protein secretion, and gene expression.



Proto-oncogenes to Oncogenes to Cancer

Oncogenes and Tumor Suppressor Genes - Tumor Genetics

Tumor Suppressor Genes - p53, pten, p21, pRB

Which one of the following statements best describes the mechanism by C. p53 is an example of an oncogene, and its expression causes uncontrolled cell division. the relationship between tumor suppressor proteins (TSP) and cancer ?.
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