With renal cell carcinoma the malignancy can begin in the

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What Is Kidney Cancer?

with renal cell carcinoma the malignancy can begin in the

The Kidney and Kidney Cancers - UCLA Urology

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Language: English French. Central to the malignant behaviour that endows cancer cells with growth advantage is their unique metabolism. Cancer cells can process nutrient molecules differently from normal cells and use it to overcome stress imposed on them by various therapies. This metabolic conversion is controlled by specific genetic mutations that are associated with activation of oncogenes and loss of tumour suppressor proteins. Understanding these processes is important as it can lead to the discovery of biomarkers that can predict the aggressiveness of the disease and its response to therapy, and even more importantly, to the development of novel therapeutics. A classic tumour in this respect is clear-cell renal cell carcinoma RCC.

Renal cell carcinoma RCC is a kidney cancer that originates in the lining of the proximal convoluted tubule , a part of the very small tubes in the kidney that transport primary urine. Initial treatment is most commonly either partial or complete removal of the affected kidney s. The body is remarkably good at hiding the symptoms and as a result people with RCC often have advanced disease by the time it is discovered. Historically, medical practitioners expected a person to present with three findings. This classic triad [8] is 1: haematuria , which is when there is blood present in the urine, 2: flank pain, which is pain on the side of the body between the hip and ribs, and 3: an abdominal mass, similar to bloating but larger. Finally, studies have found that women who have had a hysterectomy are at more than double the risk of developing RCC than those who have not. Hereditary factors have a minor impact on individual susceptibility with immediate relatives of people with RCC having a two to fourfold increased risk of developing the condition.

Skip to Content. This is the first page of Cancer. Use the menu to see other pages. Think of that menu as a roadmap for this complete guide. Every person has 2 kidneys, which are located above the waist on both sides of the spine.

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What you need to know about kidney cancer

The kidneys are bean-shaped organs located below the ribcage near the middle of your back. Most people have two kidneys, each about the size of a fist, one on each side of the spine., If detected early, RCC is curable by surgery although a minority are at risk of recurrence. Increasing incidental detection and an ageing population has led to active surveillance as an option for patients with small renal masses.

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